EverspanEducation
Longevity Pathway Map
How do interventions actually work at a molecular level? This map shows the flow from interventions → signaling nodes → cellular processes → aging outcomes. Green arrows = activation, red dashed = inhibition. Click any node to see its connections and description.
Intervention
Signaling Node
Cellular Process
Aging Outcome
Activates
Inhibits
Select a node to explore its connections
Tip: click a connected node to follow the chain
The convergence principle: Notice how most high-evidence interventions (rapamycin, caloric restriction, fasting, exercise) converge on the same two nodes – inhibiting mTORC1 and activating AMPK. This is why these pathways are considered the core longevity switches, and why combination protocols targeting multiple nodes simultaneously may be more effective than any single intervention.