Everspan organizes published research for informational purposes only. This is not medical advice. Consult a healthcare provider before starting any intervention.
Trending
BPC-157520·Semaglutide (GLP-1 Agonist)470·Rapamycin (Sirolimus)450·Nicotinamide Mononucleotide (NMN)410·Metformin380·Creatine Monohydrate340·Ashwagandha (KSM-66)290·Nicotinamide Riboside (NR)280·Vitamin D3260·Time-Restricted Eating (Intermittent Fasting)250·Cold Exposure (Cold Plunge/Shower)240·Omega-3 Fatty Acids (EPA/DHA)230·Sauna Use (Finnish-style)220·NAD+ IV Infusion210·Stem Cell Therapy200·Berberine190·Epithalon (Epitalon)180·Fisetin160·BPC-157520·Semaglutide (GLP-1 Agonist)470·Rapamycin (Sirolimus)450·Nicotinamide Mononucleotide (NMN)410·Metformin380·Creatine Monohydrate340·Ashwagandha (KSM-66)290·Nicotinamide Riboside (NR)280·Vitamin D3260·Time-Restricted Eating (Intermittent Fasting)250·Cold Exposure (Cold Plunge/Shower)240·Omega-3 Fatty Acids (EPA/DHA)230·Sauna Use (Finnish-style)220·NAD+ IV Infusion210·Stem Cell Therapy200·Berberine190·Epithalon (Epitalon)180·Fisetin160·

Intervention Atlas

Explore the full landscape of longevity interventions – organized by evidence strength, tier, and research momentum.

Showing 157 of 157 interventions

Alcohol Reduction/Elimination

Research indicates that reducing or eliminating alcohol consumption provides substantial benefits for longevity, cardiovascular health, and cellular aging markers.

A
LifestyleT1· Foundations$0–$200/mo
50 human trials
+7%

Low-Dose Aspirin

Well-studied anti-platelet therapy with extensive evidence for cardiovascular protection and potential longevity benefits.

A
PharmaceuticalT3· Advanced$2–$15/mo
200 human trials
+7%

Balance & Stability Training

Research indicates balance and stability training can significantly reduce fall risk and improve functional mobility in aging populations.

A
LifestyleT1· Foundations$0–$150/mo
150 human trials
+11%

Circadian Rhythm Management

Evidence-based light exposure, sleep timing, and behavioral strategies to optimize the body's internal clock for improved sleep and metabolic health.

A
LifestyleT1· Foundations$10–$200/mo
87 human trials
+15%

Comprehensive Blood Panel Monitoring

Regular comprehensive blood testing for early detection of health issues and optimization of biomarkers linked to longevity.

A
OtherT3· Advanced$50–$400/mo
15 human trials
+14%

Coronary Artery Calcium Score

Non-invasive CT scan that quantifies calcium deposits in coronary arteries to assess cardiovascular disease risk and guide preventive interventions.

A
OtherT3· Advanced$75–$400/mo
50 human trials
+9%

Creatine Monohydrate

One of the most well-studied supplements for muscle, brain, and cellular energy.

A
SupplementT2· Optimization$8–$20/mo
500 human trials
+10%

DEXA Scan (Body Composition)

Dual-energy X-ray absorptiometry scanning provides precise measurement of bone density, lean mass, and fat distribution for health assessment and longevity tracking.

A
OtherT3· Advanced$50–$200/mo
500 human trials
+7%

Estrogen/HRT (Menopause)

Research indicates hormone replacement therapy with estrogen may alleviate menopausal symptoms and provide cardiovascular and bone health benefits.

A
PharmaceuticalT3· Advanced$15–$300/mo
150 human trials
+5%

High Fiber Intake

Research suggests that consuming 25-35 grams of fiber daily may support longevity through improved gut health and reduced chronic disease risk.

A
LifestyleT1· Foundations$15–$60/mo
50 human trials
+8%

Flexibility & Mobility Training

Structured stretching and mobility exercises show strong evidence for improving range of motion, reducing injury risk, and supporting healthy aging.

A
LifestyleT1· Foundations$0–$150/mo
150 human trials
+11%

High-Intensity Interval Training (HIIT)

Research indicates HIIT provides superior cardiovascular and metabolic benefits compared to moderate continuous exercise in shorter time periods.

A
LifestyleT1· Foundations$0–$100/mo
150 human trials
+14%

Optimal Hydration

Maintaining proper fluid balance through adequate water intake supports cellular function, cognitive performance, and physical health.

A
LifestyleT1· Foundations$5–$50/mo
45 human trials
+9%

Iodine

Essential trace element supporting thyroid function, metabolism, and cognitive development.

A
SupplementT2· Optimization$3–$15/mo
250 human trials
+9%

Mediterranean Diet

Research indicates this traditional dietary pattern may support cardiovascular health and longevity through anti-inflammatory mechanisms.

A
LifestyleT1· Foundations$300–$600/mo
47 human trials
+17%

Oral Hygiene & Dental Health

Comprehensive oral care practices that research indicates may reduce systemic inflammation and support cardiovascular health.

A
LifestyleT1· Foundations$15–$100/mo
50 human trials
+4%

Plant-Based/Whole Food Diet

Research suggests whole food plant-based diets may support longevity through reduced chronic disease risk and improved metabolic health.

A
LifestyleT1· Foundations$200–$400/mo
45 human trials
+14%

Protein Optimization (1.6-2.2g/kg)

Consuming 1.6-2.2 grams of protein per kilogram of body weight daily to optimize muscle protein synthesis and support healthy aging.

A
LifestyleT1· Foundations$30–$200/mo
125 human trials
+11%

Psyllium Husk Fiber

A soluble fiber supplement that research indicates supports digestive health and may modestly improve cardiovascular markers.

A
SupplementT2· Optimization$8–$25/mo
47 human trials
+21%

Semaglutide (GLP-1 Agonist)

GLP-1 receptor agonist showing promising effects on metabolic health and potential longevity pathways through weight management and metabolic optimization.

A
PharmaceuticalT3· Advanced$900–$1.5k/mo
47 human trials
+9%

SGLT2 Inhibitors

Diabetes medications that research suggests may offer cardiovascular and kidney protection benefits beyond glucose control.

A
PharmaceuticalT3· Advanced$450–$650/mo
45 human trials
+15%

Sleep Hygiene Protocols

Evidence-based sleep environment and behavioral practices that research shows can significantly improve sleep quality and duration.

A
LifestyleT1· Foundations$20–$200/mo
45 human trials
+15%

Sleep Optimization

Comprehensive approach to improving sleep quality, duration, and consistency through evidence-based behavioral and environmental modifications.

A
LifestyleT1· Foundations$25–$200/mo
150 human trials
+9%

Smoking Cessation

Research shows smoking cessation significantly reduces mortality risk and improves healthspan across multiple organ systems.

A
LifestyleT1· Foundations$0–$300/mo
500 human trials
+8%

Social Connection & Community

Research indicates strong social bonds may significantly reduce mortality risk and improve healthspan across multiple biological pathways.

A
LifestyleT1· Foundations$0–$200/mo
150 human trials
+9%

Statins (for CVD Prevention)

Prescription cholesterol-lowering medications with extensive evidence for cardiovascular disease prevention.

A
PharmaceuticalT3· Advanced$10–$300/mo
150 human trials
+9%

Resistance/Strength Training

Progressive muscle strengthening exercise that research indicates may support longevity through multiple biological pathways.

A
LifestyleT1· Foundations$0–$150/mo
150 human trials
+12%

Chronic Stress Reduction

Evidence-based techniques to mitigate chronic psychological stress and its physiological impacts on aging and health.

A
LifestyleT1· Foundations$0–$200/mo
150 human trials
+6%

Thyroid Hormone Optimization

Prescription thyroid hormone replacement therapy to optimize metabolism and energy in cases of hypothyroidism or subclinical thyroid dysfunction.

A
PharmaceuticalT3· Advanced$15–$200/mo
150 human trials
-19%

Tirzepatide (Dual GIP/GLP-1 Agonist)

Dual hormone receptor agonist showing remarkable effects on weight loss and metabolic health in clinical trials.

A
PharmaceuticalT3· Advanced$900–$1.2k/mo
12 human trials
+42%

Vitamin D3

Essential vitamin supplement shown to support bone health, immune function, and potentially reduce mortality risk in deficient individuals.

A
SupplementT2· Optimization$5–$30/mo
150 human trials
+9%

VO2 Max Training

High-intensity interval training targeting maximal oxygen uptake to improve cardiovascular fitness and longevity markers.

A
LifestyleT1· Foundations$0–$200/mo
250 human trials
+11%

Daily Walking (10,000+ Steps)

Research indicates that achieving 10,000+ daily steps significantly reduces all-cause mortality and improves cardiovascular health.

A
LifestyleT1· Foundations$0–$150/mo
47 human trials
+8%

Zone 2 Cardiovascular Training

Low-intensity steady-state cardio that builds mitochondrial density and metabolic flexibility.

A
LifestyleT1· Foundations$0–$50/mo
200 human trials
+20%

Acarbose

An alpha-glucosidase inhibitor showing potential longevity benefits through metabolic modulation and caloric restriction mimetics.

B+
PharmaceuticalT3· Advanced$25–$150/mo
15 human trials
+18%

Advanced Lipid Panel (NMR/Ion Mobility)

Research indicates advanced lipid testing methods like NMR and ion mobility provide more detailed cardiovascular risk assessment than standard lipid panels.

B+
OtherT3· Advanced$100–$400/mo
15 human trials
+18%

Anti-Inflammatory Diet

Research suggests dietary patterns emphasizing anti-inflammatory foods may reduce systemic inflammation and support healthy aging.

B+
LifestyleT1· Foundations$50–$300/mo
147 human trials
+9%

Berberine

Research suggests this plant alkaloid may support metabolic health through multiple pathways including glucose regulation and lipid metabolism.

B+
SupplementT2· Optimization$15–$45/mo
45 human trials
+10%

Biological Age Testing (Epigenetic Clocks)

DNA methylation analysis to estimate biological aging rate and age-related disease risk through epigenetic clock algorithms.

B+
OtherT3· Advanced$200–$600/mo
45 human trials
+24%

Caloric Restriction

Research indicates that reducing caloric intake by 15-25% may activate longevity pathways and extend healthspan in humans.

B+
LifestyleT1· Foundations$0–$200/mo
12 human trials
+17%

Cognitive Training & Learning

Structured mental exercises designed to enhance cognitive abilities through neuroplasticity and skill-specific training.

B+
LifestyleT1· Foundations$0–$50/mo
47 human trials
+10%

Continuous Glucose Monitoring

Real-time glucose tracking device that provides continuous blood sugar insights for metabolic optimization.

B+
DeviceT2· Optimization$70–$350/mo
87 human trials
+24%

Galleri Multi-Cancer Early Detection Test

Blood-based multi-cancer early detection test using circulating tumor DNA analysis for screening asymptomatic individuals

B+
OtherT3· Advanced$949–$949/mo
8 human trials
+87%

Growth Hormone (HGH)

Research indicates recombinant human growth hormone may influence body composition, muscle mass, and metabolic parameters in adults with growth hormone deficiency.

B+
PharmaceuticalT3· Advanced$1.2k–$3.0k/mo
47 human trials
+17%

L-Theanine

Amino acid from tea that research indicates may promote relaxation and cognitive performance without sedation.

B+
SupplementT2· Optimization$8–$25/mo
18 human trials
+21%

Meditation & Mindfulness

Research indicates meditation and mindfulness practices may support cognitive function, stress reduction, and potentially healthy aging through neuroplasticity and inflammatory pathways.

B+
LifestyleT1· Foundations$0–$200/mo
47 human trials
+17%

Melatonin (Low-dose)

Research indicates low-dose melatonin may support circadian rhythm regulation and sleep quality with potential longevity benefits.

B+
SupplementT2· Optimization$3–$15/mo
47 human trials
-50%

Metformin

Diabetes medication showing promise for aging and healthspan extension in research studies

B+
PharmaceuticalT3· Advanced$4–$25/mo
47 human trials
+10%

Niacin (Nicotinic Acid/NAD+ Precursor)

B-vitamin that serves as a precursor to NAD+ and may support cardiovascular health and cellular energy metabolism.

B+
SupplementT3· Advanced$8–$25/mo
47 human trials
+5%

Extra Virgin Olive Oil Polyphenols

Research indicates extra virgin olive oil polyphenols may support cardiovascular health and provide antioxidant benefits through anti-inflammatory mechanisms.

B+
SupplementT2· Optimization$25–$80/mo
15 human trials
+17%

Omega-3 Fatty Acids (EPA/DHA)

Essential fatty acids that research suggests may support cardiovascular health, brain function, and reduce inflammation throughout the body.

B+
SupplementT2· Optimization$15–$60/mo
85 human trials
+6%

Probiotics (Multi-strain)

Research suggests multi-strain probiotics may support digestive health, immune function, and potentially cardiovascular and metabolic markers.

B+
SupplementT2· Optimization$20–$80/mo
47 human trials
+7%

Sauna Use (Finnish-style)

Regular heat exposure practice that research indicates may support cardiovascular health and longevity through hormetic stress mechanisms.

B+
LifestyleT1· Foundations$50–$200/mo
15 human trials
+27%

Testosterone Replacement Therapy (TRT)

Research indicates hormone replacement therapy for age-related testosterone decline may improve muscle mass, bone density, and sexual function in men with clinically low levels.

B+
PharmaceuticalT3· Advanced$30–$500/mo
47 human trials
+10%

Time-Restricted Eating (Intermittent Fasting)

Research indicates limiting daily eating to specific time windows may support metabolic health and longevity pathways.

B+
LifestyleT1· Foundations$0–$50/mo
47 human trials
Emerging

Vitamin C

Research indicates vitamin C supplementation may support immune function and antioxidant defense, with established evidence for preventing deficiency-related conditions.

B+
SupplementT2· Optimization$5–$30/mo
150 human trials
+7%

Zinc

Essential mineral with broad physiological roles, studied for immune function, wound healing, and age-related health optimization.

B+
SupplementT2· Optimization$5–$25/mo
150 human trials
+9%

Acetyl-L-Carnitine (ALCAR)

Research suggests acetyl-L-carnitine may support mitochondrial function, cognitive performance, and cellular energy metabolism.

B
SupplementT2· Optimization$15–$45/mo
47 human trials
+10%

Alpha-Lipoic Acid

A potent antioxidant supplement that research indicates may improve insulin sensitivity and reduce oxidative stress.

B
SupplementT2· Optimization$15–$40/mo
45 human trials
+9%

Ashwagandha (KSM-66)

Adaptogenic herb showing promise for stress reduction, cortisol management, and cognitive function in multiple human trials.

B
SupplementT2· Optimization$15–$45/mo
28 human trials
+21%

B-Vitamin Complex

Research indicates B-vitamin complexes may support energy metabolism, cognitive function, and cardiovascular health in individuals with deficiencies.

B
SupplementT2· Optimization$8–$45/mo
45 human trials
+11%

Blue Light Blocking (Evening)

Research indicates evening blue light blocking may improve sleep quality and circadian rhythm regulation.

B
DeviceT2· Optimization$2–$25/mo
15 human trials
+50%

Breathwork Protocols

Structured breathing techniques show promise for stress reduction, autonomic nervous system regulation, and mental health outcomes.

B
LifestyleT2· Optimization$0–$150/mo
47 human trials
+33%

Collagen Peptides

Research suggests hydrolyzed collagen supplements may support skin health, joint function, and bone density through enhanced collagen synthesis.

B
SupplementT2· Optimization$25–$80/mo
25 human trials
+22%

Coenzyme Q10 (CoQ10/Ubiquinol)

Antioxidant coenzyme that research suggests may support cellular energy production and cardiovascular health.

B
SupplementT2· Optimization$15–$80/mo
45 human trials
+8%

Curcumin (Turmeric Extract)

Research indicates curcumin may support anti-inflammatory pathways and cellular health through multiple mechanisms.

B
SupplementT2· Optimization$15–$60/mo
150 human trials
+6%

DHEA

Research suggests DHEA supplementation may support age-related hormonal decline and cognitive function in older adults.

B
SupplementT2· Optimization$8–$35/mo
45 human trials
+17%

Full-Body MRI Screening

Comprehensive imaging technique for early disease detection and health assessment using magnetic resonance imaging.

B
OtherT3· Advanced$1.0k–$3.0k/mo
15 human trials
+18%

Glycine

Research indicates this simple amino acid may support sleep quality and metabolic health through neurotransmitter and collagen synthesis pathways.

B
SupplementT2· Optimization$8–$25/mo
12 human trials
+15%

Green Tea Extract (EGCG)

Research suggests green tea catechins, particularly EGCG, may support metabolic health and cellular protection through antioxidant mechanisms.

B
SupplementT2· Optimization$15–$45/mo
47 human trials
+10%

Continuous Heart Rate Variability (HRV) Monitoring

Research suggests continuous HRV monitoring may provide insights into autonomic nervous system function and recovery status.

B
DeviceT2· Optimization$15–$50/mo
45 human trials
+14%

Hyperbaric Oxygen Therapy (HBOT)

Breathing pure oxygen in pressurized chambers to enhance tissue oxygenation and potentially promote healing

B
TherapyT3· Advanced$800–$4.0k/mo
85 human trials
+10%

Ketogenic Diet

A very low-carbohydrate, high-fat diet that shifts the body into ketosis for metabolic and potential longevity benefits.

B
LifestyleT1· Foundations$200–$500/mo
47 human trials
+10%

Magnesium (Glycinate/Threonate)

Research suggests these highly bioavailable magnesium forms may support sleep quality, cognitive function, and cellular energy metabolism.

B
SupplementT2· Optimization$15–$45/mo
24 human trials
+10%

N-Acetyl Cysteine (NAC)

Antioxidant supplement that research suggests may support glutathione production and respiratory health.

B
SupplementT2· Optimization$15–$40/mo
45 human trials
+9%

Nasal Breathing Practice

Research suggests conscious nasal breathing practices may improve respiratory efficiency, cardiovascular function, and autonomic nervous system balance.

B
LifestyleT1· Foundations$0–$30/mo
15 human trials
+33%

Pine Bark Extract (Pycnogenol)

Research suggests pine bark extract may support vascular health and cognitive function through potent antioxidant and anti-inflammatory mechanisms.

B
SupplementT2· Optimization$25–$80/mo
35 human trials
-12%

Red/Near-Infrared Light Therapy

Research suggests red and near-infrared light therapy may support cellular energy production and tissue repair through photobiomodulation mechanisms.

B
DeviceT2· Optimization$15–$200/mo
47 human trials
+20%

Selenium

Essential trace mineral with antioxidant properties that research suggests may support immune function and protect against oxidative stress.

B
SupplementT2· Optimization$5–$25/mo
45 human trials
+9%

Moderate Sun Exposure

Research indicates moderate sun exposure may support vitamin D synthesis, circadian rhythm regulation, and longevity through hormetic stress responses.

B
LifestyleT1· Foundations$0–$20/mo
45 human trials
+9%

Transcranial Direct Current Stimulation (tDCS)

Research indicates non-invasive brain stimulation using weak electrical currents may modulate neuroplasticity and cognitive function.

B
DeviceT3· Advanced$50–$300/mo
150 human trials
+9%

TruAge Epigenetic Clock Testing

Research-based epigenetic age testing that measures DNA methylation patterns to estimate biological aging relative to chronological age.

B
OtherT3· Advanced$300–$500/mo
15 human trials
+18%

Vagus Nerve Stimulation (VNS)

Electrical stimulation of the vagus nerve that research suggests may influence inflammation, mood, and autonomic function through parasympathetic activation.

B
DeviceT3· Advanced$200–$2.5k/mo
47 human trials
+17%

Vitamin K2 (MK-7)

A form of vitamin K2 that research suggests may support cardiovascular and bone health through calcium regulation.

B
SupplementT2· Optimization$15–$45/mo
12 human trials
+27%

Astaxanthin

A potent carotenoid antioxidant derived from microalgae that research suggests may enhance cellular protection and exercise performance.

B-
SupplementT2· Optimization$15–$60/mo
28 human trials
+10%

Black Seed Oil (Nigella Sativa)

Traditional seed oil showing promise for metabolic health, inflammation, and immune function in multiple small trials.

B-
SupplementT2· Optimization$15–$40/mo
45 human trials
+20%

Cold Exposure (Cold Plunge/Shower)

Research indicates deliberate cold exposure may enhance stress resilience, metabolism, and immune function through hormetic adaptation pathways.

B-
LifestyleT2· Optimization$0–$150/mo
15 human trials
+27%

CRISPR Gene Editing

Revolutionary gene editing technology showing promise for treating genetic diseases and potentially extending healthy lifespan.

B-
TherapyT4· Frontier$50.0k–$500.0k/mo
47 human trials
+32%

GlycanAge (Glycan-Based Biological Age Test)

Research indicates glycan-based testing may reflect biological aging through immune system glycoprotein analysis.

B-
OtherT3· Advanced$300–$500/mo
8 human trials
+25%

Lion's Mane Mushroom

Research suggests this medicinal mushroom may support cognitive function and nerve health through neurotrophic compounds.

B-
SupplementT2· Optimization$15–$60/mo
8 human trials
+24%

Low-Dose Lithium

Research suggests very low doses of lithium may support neuroprotection and longevity through multiple cellular pathways.

B-
PharmaceuticalT3· Advanced$15–$60/mo
12 human trials
+15%

Gut Microbiome Testing

Direct-to-consumer testing to analyze gut bacterial composition and diversity for personalized health insights.

B-
OtherT2· Optimization$100–$400/mo
45 human trials
+9%

Nicotinamide Riboside (NR)

NAD+ precursor supplement studied for cellular energy metabolism and potential anti-aging effects.

B-
SupplementT3· Advanced$45–$120/mo
12 human trials
+24%

Nicotinamide Mononucleotide (NMN)

NAD+ precursor supplement that research suggests may support cellular energy metabolism and healthy aging pathways.

B-
SupplementT3· Advanced$45–$150/mo
8 human trials
+17%

Palmitoylethanolamide (PEA)

Research indicates that palmitoylethanolamide (PEA) may support pain management and inflammatory responses through endocannabinoid system modulation.

B-
SupplementT2· Optimization$25–$80/mo
18 human trials
+11%

Phosphatidylserine

Research suggests this phospholipid supplement may support cognitive function and stress response in aging adults.

B-
SupplementT2· Optimization$25–$60/mo
15 human trials
-18%

PT-141 (Bremelanotide)

Research indicates this melanocortin receptor agonist may influence sexual function and metabolic parameters.

B-
PharmaceuticalT3· Advanced$200–$800/mo
8 human trials
+50%

Quercetin

Flavonoid antioxidant studied for anti-inflammatory and senolytic properties in aging research

B-
SupplementT2· Optimization$15–$60/mo
25 human trials
+9%

Rapamycin (Sirolimus)

An mTOR inhibitor showing lifespan extension in animal models, now under investigation for human aging.

B-
PharmaceuticalT3· Advanced$50–$200/mo
15 human trials
+18%

Resveratrol

A polyphenolic compound from red grapes studied for its potential anti-aging and cardiovascular benefits.

B-
SupplementT2· Optimization$15–$80/mo
85 human trials
+3%

Spermidine

A naturally occurring polyamine that research suggests may support cellular autophagy and longevity pathways.

B-
SupplementT2· Optimization$25–$60/mo
8 human trials
+10%

SS-31 (Elamipretide)

Mitochondria-targeting peptide investigated for treating mitochondrial dysfunction and age-related diseases.

B-
PharmaceuticalT3· Advanced$8.0k–$15.0k/mo
12 human trials
-18%

Sulforaphane (Broccoli Extract)

A potent antioxidant compound from cruciferous vegetables showing promise for cellular protection and longevity pathways.

B-
SupplementT2· Optimization$25–$80/mo
15 human trials
+9%

Tadalafil (Low-Dose)

PDE5 inhibitor with cardiovascular, vascular, and emerging longevity benefits beyond its primary indication

B-
PharmaceuticalT3· Advanced$15–$60/mo
89 human trials
+20%

Taurine

Research suggests this naturally occurring amino acid derivative may support cardiovascular health and cellular protection through multiple mechanisms.

B-
SupplementT2· Optimization$8–$25/mo
18 human trials
+17%

Thymosin Alpha-1

A synthetic peptide derived from thymosin that modulates immune function and has been studied for enhancing T-cell activity.

B-
PharmaceuticalT3· Advanced$300–$800/mo
15 human trials
Emerging

Tongkat Ali (Eurycoma Longifolia)

Research suggests this traditional Southeast Asian herb may support testosterone levels and stress response in men.

B-
SupplementT2· Optimization$25–$80/mo
12 human trials
+29%

Urolithin A

A mitophagy-enhancing metabolite that research suggests may support muscle function and cellular health

B-
SupplementT2· Optimization$89–$179/mo
8 human trials
+34%

AI-Driven Drug Discovery for Aging

Artificial intelligence platforms accelerate identification of novel anti-aging compounds through computational drug discovery and repurposing.

C+
OtherT4· Frontier$10.0k–$100.0k/mo
0 human trials
+41%

AI-Personalized Nutrition

Machine learning algorithms analyze individual biomarkers and genetics to create personalized dietary recommendations for optimal health outcomes.

C+
OtherT3· Advanced$150–$500/mo
12 human trials
+52%

Apigenin

Research suggests apigenin, a flavonoid found in chamomile and parsley, may support cellular longevity through multiple anti-aging pathways.

C+
SupplementT2· Optimization$15–$45/mo
8 human trials
-47%

Boron

Research indicates boron supplementation may support bone health and hormone optimization through mineral metabolism pathways.

C+
SupplementT2· Optimization$8–$25/mo
8 human trials
+25%

BPC-157

Synthetic peptide derived from gastric juice showing promise for tissue repair and wound healing in animal studies.

C+
PharmaceuticalT3· Advanced$200–$800/mo
2 human trials
+27%

Brain-Computer Interfaces

Direct neural interface devices that decode brain signals to control external systems or stimulate neural activity.

C+
DeviceT4· Frontier$5.0k–$50.0k/mo
45 human trials
+16%

C15:0 (Pentadecanoic Acid / Fatty15)

Research suggests C15:0 may support cellular membrane health and metabolic function as an essential odd-chain fatty acid.

C+
SupplementT2· Optimization$30–$60/mo
2 human trials
Emerging

Cistanche Tubulosa

Traditional desert herb studied for potential testosterone support and kidney function benefits

C+
SupplementT2· Optimization$25–$60/mo
4 human trials
Emerging

Dasatinib + Quercetin (Senolytic)

Research indicates this combination therapy may selectively eliminate senescent cells to slow aging processes.

C+
PharmaceuticalT3· Advanced$150–$800/mo
8 human trials
+28%

Dasatinib (Standalone Senolytic)

Cancer drug repurposed as a senolytic to selectively eliminate aging cells, showing promise in early human trials.

C+
PharmaceuticalT3· Advanced$400–$1.2k/mo
4 human trials
+25%

Ecdysterone (Beta-Ecdysterone)

Plant-derived steroid compound studied for muscle-building and metabolic benefits.

C+
SupplementT2· Optimization$25–$80/mo
4 human trials
+50%

Epithalon (Epitalon)

Synthetic tetrapeptide investigated for potential telomerase activation and age-related biomarker effects.

C+
PharmaceuticalT3· Advanced$80–$300/mo
3 human trials
Emerging

Ergothioneine

Research suggests this 'longevity vitamin' may support cellular protection and mitochondrial health through its unique antioxidant properties.

C+
SupplementT2· Optimization$25–$60/mo
8 human trials
+18%

Exosome Therapy

Extracellular vesicles containing cellular communication molecules used for tissue repair and regenerative medicine applications.

C+
TherapyT4· Frontier$3.0k–$15.0k/mo
15 human trials
+14%

Fisetin

A flavonoid compound studied for its potential senolytic properties and cognitive benefits.

C+
SupplementT2· Optimization$25–$60/mo
3 human trials
-10%

Gene Therapy (Follistatin, Telomerase, etc.)

Direct genetic modification to enhance muscle growth, extend telomeres, or modify cellular function through viral vector delivery.

C+
TherapyT4· Frontier$50.0k–$200.0k/mo
8 human trials
+17%

Ghrelin Mimetics (MK-677/Ipamorelin)

Growth hormone secretagogues that stimulate natural GH release, showing promise for muscle growth, bone density, and sleep quality improvements.

C+
PharmaceuticalT3· Advanced$120–$400/mo
15 human trials
Emerging

Grounding/Earthing

Research suggests direct skin contact with the Earth's surface may influence inflammation and stress responses through electron transfer.

C+
LifestyleT2· Optimization$0–$150/mo
8 human trials
Emerging

Methylene Blue (Low-dose)

Research suggests low-dose methylene blue may support cellular energy production and cognitive function through mitochondrial enhancement.

C+
PharmaceuticalT3· Advanced$15–$45/mo
8 human trials
Emerging

Mitochondrial Transplantation

Experimental procedure involving direct transplantation of healthy mitochondria into cells to restore cellular energy production

C+
TherapyT4· Frontier$15.0k–$50.0k/mo
3 human trials
+47%

Mouth Taping (Nasal Breathing Training)

Research suggests mouth taping during sleep may improve nasal breathing patterns and sleep quality

C+
LifestyleT2· Optimization$5–$25/mo
6 human trials
Emerging

NAD+ IV Infusion

Intravenous delivery of NAD+ precursors aims to restore cellular energy metabolism and support mitochondrial function.

C+
TherapyT3· Advanced$800–$2.4k/mo
4 human trials
+50%

Nanotechnology Medicine

Engineered nanoparticles for targeted drug delivery and therapeutic applications in aging-related diseases.

C+
TherapyT4· Frontier$2.0k–$15.0k/mo
47 human trials
+18%

Ozone Therapy

Research indicates ozone therapy may modulate immune function and oxidative stress through controlled ozone exposure.

C+
TherapyT3· Advanced$200–$1.5k/mo
12 human trials
+18%

Pyrroloquinoline Quinone (PQQ)

A vitamin-like compound that research indicates may support mitochondrial function and cellular energy metabolism.

C+
SupplementT2· Optimization$25–$60/mo
8 human trials
+28%

Rapamycin + Metformin Combination

Research suggests combining mTOR inhibition with metabolic modulation may enhance longevity pathways more than either drug alone.

C+
PharmaceuticalT3· Advanced$150–$400/mo
8 human trials
+28%

Topical Rapamycin (Skin Aging)

Research suggests topical rapamycin may reduce skin aging through mTOR pathway inhibition.

C+
PharmaceuticalT3· Advanced$150–$400/mo
3 human trials
+50%

Next-Gen Senolytics (Clinical Pipeline)

Experimental small molecule compounds designed to selectively eliminate senescent cells through novel mechanisms beyond current dasatinib-quercetin approaches.

C+
PharmaceuticalT4· Frontier$0–$0/mo
8 human trials
+52%

Shilajit (Purified Fulvic Acid Complex)

Research suggests this mineral-rich Himalayan compound may support testosterone, mitochondrial function, and cognitive performance

C+
SupplementT2· Optimization$25–$80/mo
8 human trials
+28%

Stem Cell Therapy

Regenerative medicine approach using stem cells to repair or replace damaged tissues.

C+
TherapyT4· Frontier$5.0k–$50.0k/mo
45 human trials
+11%

Telomere Extension Therapies

Research investigates therapies targeting telomerase activation and telomere lengthening to potentially slow cellular aging.

C+
TherapyT4· Frontier$500–$15.0k/mo
8 human trials
+17%

Turkesterone

Research indicates this ecdysteroid compound may support muscle protein synthesis and exercise performance through non-androgenic pathways.

C+
SupplementT2· Optimization$25–$80/mo
3 human trials
Emerging

UBX0101 (Senolytic for Osteoarthritis)

Experimental senolytic drug targeting senescent cells in knee osteoarthritis through localized injection.

C+
PharmaceuticalT4· Frontier$5.0k–$15.0k/mo
2 human trials
Emerging

Xenotransplantation (Pig Organs)

Transplantation of genetically modified pig organs to replace failing human organs, representing the frontier of regenerative medicine.

C+
TherapyT4· Frontier$500.0k–$2000.0k/mo
8 human trials
+25%

Young Plasma Exchange/Parabiosis

Experimental procedure involving exchange of young blood plasma with the aim of reversing age-related decline through circulating factors.

C+
TherapyT4· Frontier$8.0k–$15.0k/mo
8 human trials
-10%

FOXO4-DRI (Senolytic Peptide)

Research-stage senolytic peptide designed to selectively eliminate senescent cells through FOXO4-p53 pathway disruption.

C
PharmaceuticalT3· Advanced$2.0k–$5.0k/mo
0 human trials
Emerging

Navitoclax (ABT-263)

Experimental BCL-2/BCL-xL inhibitor investigated as a senolytic drug to eliminate senescent cells

C
PharmaceuticalT4· Frontier$15.0k–$25.0k/mo
8 human trials
+21%

3D Organ Bioprinting

Research explores 3D bioprinting technology to create functional organs and tissues for transplantation and regenerative medicine applications.

C
TherapyT4· Frontier$500.0k–$2000.0k/mo
5 human trials
+13%

Partial Cellular Reprogramming (Yamanaka Factors)

Experimental cellular reprogramming technology using Yamanaka factors to potentially reverse cellular aging without full pluripotency induction.

C
TherapyT4· Frontier$10.0k–$50.0k/mo
0 human trials
+41%

17-alpha-Estradiol

Research suggests this estrogen stereoisomer may extend lifespan in male mice while avoiding feminizing effects.

D
PharmaceuticalT3· Advanced$200–$800/mo
0 human trials
Emerging

Cellular Senescence Vaccine

Experimental immunotherapy approach targeting senescent cells by training the immune system to recognize and eliminate them.

D
TherapyT4· Frontier$5.0k–$15.0k/mo
0 human trials
+18%

Chemical Epigenetic Reprogramming (Yamanaka-Free)

Small molecule cocktails aimed at reversing cellular aging without genetic modification through chemical epigenetic reset.

D
TherapyT4· Frontier$500–$5.0k/mo
0 human trials
+88%

Fadogia Agrestis

West African plant extract studied for potential testosterone-supporting effects, but human evidence remains extremely limited.

D
SupplementT2· Optimization$25–$60/mo
0 human trials
Emerging

GDF11 (Growth Differentiation Factor 11)

Circulating protein factor that research suggests may restore youthful tissue regeneration and reverse age-related decline

D
TherapyT4· Frontier$5.0k–$15.0k/mo
0 human trials
+18%

Klotho Protein Therapy

Experimental protein therapy targeting the anti-aging hormone klotho to potentially reverse cellular aging and improve healthspan.

D
TherapyT4· Frontier$10.0k–$50.0k/mo
0 human trials
+10%

mRNA Longevity Therapies

Experimental mRNA therapies designed to reprogram cellular aging pathways and enhance longevity through targeted genetic interventions.

D
TherapyT4· Frontier$50.0k–$200.0k/mo
0 human trials
+87%

Whole-Body Organ Replacement

Research explores complete organ system replacement as a potential approach to address age-related organ failure and extend human lifespan.

D
TherapyT4· Frontier$5000.0k–$50000.0k/mo
0 human trials
+25%

Cryonics/Cryopreservation

Theoretical preservation of human remains at ultra-low temperatures with the hope of future revival, though no successful human resuscitation has been achieved.

F
OtherT4· Frontier$250–$2.5k/mo
0 human trials
+25%

Digital Consciousness/Mind Upload

Theoretical process of transferring human consciousness to digital substrate for potential immortality through technological transcendence.

F
OtherT4· Frontier$0–$0/mo
0 human trials
+25%