EverspanVitamin K2 (MK-7)
A form of vitamin K2 that research suggests may support cardiovascular and bone health through calcium regulation.
Human Trials
12
2,847 participants
Risk Level
Monthly Cost
Price varies significantly by dosage (45-200 mcg) and brand quality
Quick Facts
- Category
- Supplement
- Research Field
- Supplements
- Evidence Grade
- B – Moderate
- Risk Level
- Low
- Monthly Cost
- $15 – $45
- Human Trials
- 12
Typical Dose
100–200 mcg MK-7/day
Range
45–360 mcg/day MK-7
For informational purposes only – not medical advice. See disclaimer
Research Velocity
Mechanism of Action
Vitamin K2 (MK-7) functions as a cofactor for gamma-glutamyl carboxylase, which activates proteins involved in calcium homeostasis. Research indicates it activates osteocalcin in bones to bind calcium and matrix Gla protein (MGP) in arteries to prevent calcium deposition. Studies suggest this dual action may help direct calcium to bones while preventing arterial calcification.
Overview
Vitamin K2 (MK-7) is a fat-soluble vitamin that research indicates plays crucial roles in calcium metabolism and cardiovascular health. Studies suggest that MK-7, derived primarily from fermented foods like natto, has superior bioavailability and longer half-life compared to other forms of vitamin K. The compound appears to work by activating proteins that help direct calcium to appropriate tissues - promoting bone mineralization while potentially preventing arterial calcification.
Clinical research indicates that MK-7 supplementation may improve arterial stiffness and reduce coronary artery calcification, particularly in postmenopausal women. Studies also suggest benefits for bone health, with some trials showing improvements in bone mineral density and reduced fracture risk. The typical effective dosage ranges from 45-180 mcg daily, with higher doses showing greater effects on biochemical markers of bone and cardiovascular health.
While generally well-tolerated, research indicates that vitamin K2 supplementation should be approached cautiously by individuals taking anticoagulant medications, as it may interfere with their effectiveness. The supplement appears most beneficial for populations at risk of vitamin K2 deficiency, including those with limited fermented food intake or certain gastrointestinal conditions that affect fat absorption.
Known Interactions
- May reduce effectiveness of warfarin and other vitamin K antagonist anticoagulants
- Potential interaction with antibiotics that affect vitamin K-producing gut bacteria
- May interact with orlistat and other fat absorption inhibitors
Legal Status by Country
Your country (United States)
Available without prescription in:
Australia, Brazil, Canada, China, Colombia, Germany, India, Israel, Japan, Mexico, Netherlands, Panama, Russia, South Korea, Switzerland, Thailand, Turkey, UAE, United Kingdom, United States
📍 = your selected country · ✈️ = medical tourism destination · Always verify current local regulations before travel.
Key Research
- 2019
Primary efficacy study on cardiovascular outcomes
- 2013
Bone health mechanism validation
- 2015
Comprehensive meta-analysis of bone outcomes
- 2004Vitamin K2 and Coronary Artery Calcification: The Rotterdam Study
Foundational epidemiological study on cardiovascular benefits
- 2020
Comprehensive review of clinical applications
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Last verified: 2026-03-16