Ashwagandha (KSM-66)
Adaptogenic herb showing promise for stress reduction, cortisol management, and cognitive function in multiple human trials.
Human Trials
28
2,150 participants
Risk Level
Monthly Cost
Based on 300-600mg daily dosing of standardized KSM-66 extract
Quick Facts
- Category
- Supplement
- Research Field
- Supplements
- Evidence Grade
- B – Moderate
- Risk Level
- Low
- Monthly Cost
- $15 – $45
- Human Trials
- 28
Typical Dose
300–600 mg/day (standardized root extract)
Range
300–1200 mg/day
For informational purposes only – not medical advice. See disclaimer
Research Velocity
Mechanism of Action
KSM-66 ashwagandha acts as an adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing cortisol levels. Research indicates it influences GABA signaling pathways and may affect neurotransmitter balance. The withanolides, particularly withanoside IV and withanoside VI, appear to be the primary bioactive compounds responsible for its stress-reducing and neuroprotective effects.
Overview
KSM-66 ashwagandha is a patented, full-spectrum extract of Withania somnifera root that has demonstrated consistent benefits in multiple human trials. Research indicates this adaptogenic herb may help reduce perceived stress levels, lower cortisol concentrations, and improve stress-related symptoms including anxiety and sleep quality. Studies suggest KSM-66 may also support cognitive function, with some trials showing improvements in attention, information processing speed, and executive function in stressed adults.
The extract has shown a favorable safety profile in clinical trials, with most studies reporting minimal adverse effects when used at standard dosages of 300-600mg daily. Research indicates KSM-66 may also support physical performance, with some studies suggesting benefits for muscle strength, muscle mass, and exercise recovery. Additionally, preliminary evidence suggests potential benefits for thyroid function, though more research is needed to establish definitive effects.
While the research foundation for KSM-66 ashwagandha is growing, most individual studies have been relatively small and of short duration. The evidence base would benefit from larger, longer-term trials to better establish optimal dosing protocols and long-term safety. Despite these limitations, the consistency of positive findings across multiple domains makes KSM-66 one of the better-researched adaptogenic supplements currently available.
Known Interactions
- May enhance effects of sedative medications and benzodiazepines
- Potential interaction with thyroid medications due to thyroid hormone modulation
- May interact with immunosuppressant drugs by potentially boosting immune function
- Possible interaction with diabetes medications due to blood sugar lowering effects
- May enhance effects of blood pressure medications
Legal Status by Country
Your country (United States)
Available without prescription in:
Australia, Brazil, Canada, China, Colombia, Germany, India, Israel, Japan, Mexico, Netherlands, Russia, South Korea, Switzerland, Thailand, Turkey, UAE, United Kingdom, United States, Panama
📍 = your selected country · ✈️ = medical tourism destination · Always verify current local regulations before travel.
Key Research
- 2019
Weight management and stress reduction study
- 2019
Comprehensive stress and cortisol reduction trial
- 2019Other161 citations
Cognitive function and attention improvement study
- 2021Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep quality and mental alertness
Sleep quality and mental performance assessment
- 2017
Foundational stress reduction and anxiety study
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Last verified: 2026-03-16