Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric Oxygen Therapy (HBOT) involves breathing pure oxygen while inside a pressurized chamber, typically at 1.4 to 3.0 times normal atmospheric pressure. Research indicates this treatment significantly increases oxygen levels in blood plasma and tissues, potentially promoting cellular repair mechanisms and reducing inflammation. Studies suggest HBOT may enhance wound healing, improve cognitive function in older adults, and show promise for various age-related conditions including chronic fatigue and tissue damage.

Recent clinical trials have demonstrated intriguing longevity-related effects, with one study showing increased telomere length and reduced cellular senescence markers in healthy older adults after a series of HBOT sessions. Research indicates the therapy may stimulate angiogenesis (new blood vessel formation), enhance mitochondrial function, and activate cellular repair pathways. However, most longevity applications remain investigational, with established medical uses primarily focused on decompression sickness, carbon monoxide poisoning, and chronic non-healing wounds.

While generally considered safe when properly administered, HBOT carries risks including ear barotrauma, temporary vision changes, and rare cases of oxygen toxicity or lung complications. The therapy requires specialized facilities and trained personnel, making it relatively expensive and less accessible than other interventions. Treatment protocols typically involve multiple sessions over weeks to months, with effects potentially lasting several months post-treatment according to some studies.