Coronary Artery Calcium Score
Non-invasive CT scan that quantifies calcium deposits in coronary arteries to assess cardiovascular disease risk and guide preventive interventions.
Human Trials
50
75,000 participants
Risk Level
Monthly Cost
One-time test typically repeated every 3-5 years
Quick Facts
- Category
- Other
- Research Field
- Other
- Evidence Grade
- A – Strong
- Risk Level
- Low
- Monthly Cost
- $75 – $400
- Human Trials
- 50
Research Velocity
Mechanism of Action
Coronary artery calcium (CAC) scoring uses computed tomography to detect and quantify calcified plaque deposits in the coronary arteries. Research indicates that calcium deposition occurs in atherosclerotic plaques as part of the inflammatory process of coronary artery disease. Studies suggest that CAC scores correlate strongly with total plaque burden and provide superior risk stratification compared to traditional risk factors alone. The Agatston score, the most common measurement method, multiplies plaque area by density factor to generate a numerical risk assessment.
Overview
**Coronary Artery Calcium (CAC) scoring represents one of the most validated cardiovascular risk assessment tools available today.** Research indicates that this non-invasive CT scan can detect calcified plaque deposits in the coronary arteries years before symptoms develop, providing crucial information for risk stratification and treatment decisions. Studies suggest that CAC scoring significantly improves cardiovascular risk prediction beyond traditional risk factors like cholesterol levels, blood pressure, and family history, particularly in intermediate-risk patients where treatment decisions are uncertain.
**The test involves a brief, low-dose CT scan that takes just minutes to complete and requires no contrast dye or special preparation.** Research demonstrates that CAC scores correlate strongly with future cardiovascular events, with higher scores indicating exponentially increased risk. Studies indicate that a CAC score of zero is associated with very low risk of cardiac events over the next 10-15 years, while scores above 300 suggest significantly elevated risk requiring aggressive preventive interventions.
**Clinical guidelines now incorporate CAC scoring as a "tie-breaker" for patients at intermediate cardiovascular risk, helping clinicians and patients make informed decisions about statin therapy and other preventive measures.** Research suggests that CAC results often motivate lifestyle changes and improve medication adherence when elevated scores are discovered. While the test provides valuable prognostic information, studies indicate it's most beneficial for asymptomatic adults aged 40-75 with intermediate risk factors, as very young or very high-risk patients may not benefit from additional risk stratification.
Known Interactions
- Radiation exposure approximately 1-1.5 mSv per scan
- May not detect non-calcified plaque or soft plaque deposits
- Results can be affected by patient movement or irregular heart rhythm
- Not recommended for patients under 40 without significant risk factors
Legal Status by Country
Your country (United States)
Available at imaging centers, often without physician referral
Available without prescription in:
United States
📍 = your selected country · ✈️ = medical tourism destination · Always verify current local regulations before travel.
Key Research
- 2010
Landmark validation study
- 2018
Clinical guidelines incorporating CAC
- 2021
Long-term mortality outcomes
- 2008Coronary calcium as a predictor of coronary events in four racial or ethnic groups
Multi-ethnic validation study
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Last verified: 2026-03-16