Quercetin

Quercetin is a naturally occurring flavonoid found in foods like onions, apples, and berries that has gained attention in longevity research for its potential anti-aging properties. Studies suggest it functions as both a powerful antioxidant and anti-inflammatory compound, with emerging research indicating it may act as a senolytic agent–selectively targeting and eliminating senescent "zombie" cells that contribute to aging and age-related diseases. Research has shown quercetin can reduce inflammatory markers and may support cardiovascular health, though its bioavailability in standard forms is relatively low.

Human trials have explored quercetin's effects on various health parameters, including cardiovascular function, exercise performance, and inflammatory markers. While results are promising, most studies have been relatively small or short-term. Research indicates that quercetin supplementation may help reduce blood pressure, improve endothelial function, and decrease inflammatory cytokines in some populations. The compound's potential senolytic effects, while demonstrated in animal studies and laboratory research, require more extensive human validation.

Quercetin supplements are widely available and generally well-tolerated, though absorption can be enhanced through formulations that include bromelain or liposomal delivery systems. Studies suggest typical dosing ranges from 500-1000mg daily, though optimal dosing for anti-aging benefits remains under investigation. While quercetin shows promise as a longevity intervention, researchers emphasize that more long-term human studies are needed to fully establish its efficacy for healthy aging and lifespan extension.