Boron
Research indicates boron supplementation may support bone health and hormone optimization through mineral metabolism pathways.
Human Trials
8
312 participants
Risk Level
Monthly Cost
Basic boron supplements are inexpensive; chelated forms cost more
Quick Facts
- Category
- Supplement
- Research Field
- Supplements
- Evidence Grade
- C+ – Early
- Risk Level
- Low
- Monthly Cost
- $8 – $25
- Human Trials
- 8
Research Velocity
Mechanism of Action
Research suggests boron influences mineral metabolism by affecting calcium, magnesium, and phosphorus absorption and retention. Studies indicate it may modulate steroid hormone metabolism, particularly testosterone and estrogen, through interactions with steroid hormone-binding globulin. Boron appears to support bone mineralization by enhancing vitamin D utilization and calcium incorporation into bone matrix.
Overview
Boron is a trace mineral that research suggests plays important roles in bone health and hormone metabolism. Studies indicate that boron supplementation may support calcium and magnesium retention, potentially benefiting bone mineral density and reducing calcium excretion. The mineral appears to influence steroid hormone metabolism, with some research showing modest increases in testosterone levels and changes in estrogen metabolism in both men and women.
Human trials investigating boron supplementation have been relatively small but suggest potential benefits for bone health markers and mineral metabolism. Research indicates typical supplemental doses range from 3-10mg daily, with most studies using doses in the lower end of this range. While boron deficiency appears uncommon in populations with varied diets, some research suggests that marginal intake may be more prevalent than previously thought.
The supplement market offers boron in various forms including boron citrate, boron glycinate, and sodium borate, with chelated forms potentially offering better absorption. Research indicates boron is generally well-tolerated at supplemental doses, though very high intakes may cause gastrointestinal upset. Most studies suggest benefits may be more pronounced in individuals with lower baseline boron status or suboptimal mineral intake from diet.
Known Interactions
- May enhance magnesium absorption and retention
- Could potentially affect estrogen metabolism - monitor with hormone-sensitive conditions
- May interact with medications affecting mineral balance
Legal Status by Country
Your country (United States)
Available without prescription in:
Australia, Brazil, Canada, China, Colombia, Germany, India, Israel, Japan, Mexico, Netherlands, Panama, Russia, South Korea, Switzerland, Thailand, Turkey, UAE, United Kingdom, United States
📍 = your selected country · ✈️ = medical tourism destination · Always verify current local regulations before travel.
Key Research
- 1987
Foundational study on boron's effects on mineral metabolism
- 2011
Human trial examining hormone effects
- 2011
Bone health outcomes in humans
- 2019Boron and bone health: a systematic review of human studies
Recent systematic review of human evidence
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Last verified: 2026-03-16