Education

NAD⁺ Decline Across the Lifespan

Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme essential for energy metabolism, DNA repair, and sirtuin activity. Levels fall ~50% by age 60 in most tissues – and this decline is now considered a primary driver of multiple hallmarks of aging. Hover the legend to isolate individual tissue curves.

NAD⁺ Levels Across the Lifespan

Relative tissue NAD⁺ concentration vs age 20 baseline (100%)

~50%

decline by age 60

Across most tissues

2–3×

NAD+ boost from NMN/NR

Demonstrated in clinical trials

1.5×

slower decline with exercise

Zone 2 cardio especially

NAD⁺-Boosting Interventions in the Atlas

B-NMN B-NR B+Zone 2 Cardio B+Time-Restricted Eating B-Sauna B+Caloric Restriction

NAD+ Decline Across the Lifespan

NAD+ Levels Across the Lifespan

NAD⁺ Decline Across the Lifespan

NAD⁺ Levels Across the Lifespan