EverspanLongevity Guides
Condition-specific protocols that map the best-evidence interventions to your health goals — built from the same research database powering the Intervention Atlas.
Best Interventions for Metabolic Syndrome
A comprehensive, evidence-ranked protocol for reversing the cluster of conditions — high blood sugar, excess abdominal fat, abnormal cholesterol, and high blood pressure — that define metabolic syndrome.
Affects 1 in 3 adults over 40
Reducing Cardiovascular Risk: A Longevity Protocol
Evidence-based strategies for lowering atherosclerotic cardiovascular disease risk, from foundational lifestyle to advanced diagnostics and targeted pharmaceuticals.
CVD remains the #1 cause of death in adults over 50
Preventing Cognitive Decline: Evidence-Based Strategies
A multi-modal protocol targeting the primary drivers of age-related cognitive decline: neuroinflammation, vascular damage, mitochondrial dysfunction, and impaired synaptic plasticity.
Dementia risk increases 5-fold for every decade over 65
Longevity Protocol for ApoE4 Carriers
A personalized intervention framework for individuals carrying one or two copies of the ApoE4 allele — the most significant genetic risk factor for late-onset Alzheimer's disease.
ApoE4 affects ~25% of the population; doubles Alzheimer's risk in heterozygotes
Systemic Inflammation Reduction Protocol
Evidence-based strategies to lower chronic low-grade inflammation — the common driver behind cardiovascular disease, metabolic dysfunction, neurodegeneration, and accelerated aging.
Chronic inflammation is implicated in 7 of the top 10 causes of death
The Longevity Maximalist Stack
A comprehensive, tier-1 focused protocol for individuals pursuing maximum health span and lifespan extension through the full toolkit of evidence-based interventions.
The longevity field has doubled in research output in 5 years
Hormonal Optimization for Longevity
A structured approach to maintaining optimal hormone levels throughout aging, covering testosterone, estrogen, thyroid, DHEA, and growth hormone.
Testosterone declines 1–2% per year in men after age 30
Optimizing Gut Health for Longevity
The gut microbiome is a master regulator of immune function, inflammation, metabolic health, and even cognitive performance. This guide covers evidence-based strategies to cultivate a longevity-supportive microbiome.
The gut microbiome contains ~100 trillion bacteria influencing every organ system
Cancer Prevention: Evidence-Based Risk Reduction
A proactive framework for reducing cancer incidence through lifestyle modification, early detection diagnostics, and evidence-based interventions targeting cancer hallmarks.
40% of cancer cases are attributable to modifiable risk factors
Diabetes Prevention and Reversal Protocol
A comprehensive evidence-based protocol for preventing progression from prediabetes to type 2 diabetes, and for supporting metabolic reversal in early-stage disease.
88 million American adults have prediabetes — 84% don't know it
Sleep Optimization: The Foundation of Longevity
Sleep is the single most impactful, cost-free longevity intervention available. This guide covers the evidence and practical protocol for achieving restorative, consistent sleep.
Short sleepers (<6h) have 70% higher all-cause mortality risk
Athletic Performance and Recovery for Longevity Athletes
Optimizing performance, accelerating recovery, and maintaining athletic capacity deep into aging — the intersection of sports science and longevity medicine.
VO2 max is the single strongest predictor of longevity — stronger than any biomarker