Research Studies

Higher cardiorespiratory fitness was linearly associated with lower all-cause mortality; the highest fitness group had 4× lower risk than the least fit.

NMN supplementation (250 mg/day) increased skeletal muscle insulin sensitivity and signaling in postmenopausal women with prediabetes.

Omega-3 supplementation (1 g/day) reduced major cardiovascular events by 28% in those not consuming fish regularly.

25% caloric restriction over 2 years significantly improved cardiometabolic risk factors including blood pressure, lipids, and insulin resistance in non-obese adults.

A 3-day course of dasatinib + quercetin reduced senescent cell burden in adipose tissue by 50% and improved physical function metrics in older adults.

Curcumin supplementation significantly reduced CRP and IL-6 levels in adults, particularly in those with chronic disease and higher baseline inflammation.

Lactate threshold training at Zone 2 intensity uniquely improves mitochondrial lactate oxidation and metabolic flexibility in trained and untrained individuals.

Highest dietary spermidine intake was associated with significantly lower all-cause mortality and reduced cardiovascular risk over 20 years.

Fisetin reduced senescent cell burden in multiple tissues, improved physical function, and extended median and maximum lifespan in aged mice.

Bioavailable curcumin (Theracurmin 90 mg twice daily) significantly improved memory and attention in non-demented adults over 18 months.

Short-term rapamycin improved cardiac function (ejection fraction) in middle-aged pet dogs without significant adverse effects.

30% caloric restriction started in adult and old rhesus monkeys delayed age-associated disease onset by 50% and reduced mortality risk.

HIIT reversed many age-related differences in muscle mitochondrial function and ribosomal capacity, with older adults gaining as much as younger adults.

Landmark trial designed to test metformin as the first drug targeting aging as a disease in non-diabetic older adults.

Oral NR supplementation dose-dependently elevated whole blood NAD+ levels in healthy adults without clinically relevant side effects.

Metformin use associated with significantly reduced cancer incidence and cancer-related mortality in diabetic patients.

Low-dose mTOR inhibitor (RAD001) improved response to influenza vaccine by 20% in elderly volunteers, suggesting immune rejuvenation.

Creatine supplementation significantly preserved lean muscle mass and functional strength in older adults (>55 years), attenuating age-related sarcopenia.

Metformin extends mouse lifespan by 5.83% via AMPK activation and oxidative stress reduction, mimicking caloric restriction.

Sleep activates the glymphatic system, increasing cerebrospinal fluid flow and clearing Alzheimer's-related amyloid-beta by 61% more than waking.

Higher magnesium intake was inversely associated with all-cause mortality and cardiovascular disease; the effect was strongest for sudden cardiac death.

Metformin monotherapy associated with lower all-cause mortality and cardiovascular events compared with sulfonylurea monotherapy.

Berberine reduced HbA1c by 0.9%, fasting glucose by 1.13 mmol/L, and postprandial glucose by 2.38 mmol/L — comparable to metformin.

Resveratrol (500 mg/day) improved insulin sensitivity and reduced fasting glucose in overweight adults with metabolic syndrome.

Daily magnesium supplementation (365 mg) significantly improved fasting glucose, insulin sensitivity, and blood pressure in overweight, non-diabetic adults.

Moderate-intensity endurance training significantly increased mitochondrial biogenesis markers (PGC-1α) and oxidative enzyme capacity in skeletal muscle.

Higher blood omega-3 levels were associated with significantly slower telomere attrition over 5 years in patients with coronary heart disease.

Rapamycin started at 600 days of age extended mouse median lifespan by 28% in females and 23% in males — even when started late in life.

Both short (<6h) and long (>9h) sleep duration were associated with significantly increased all-cause mortality; optimal sleep was 7–8 hours.

Exogenous spermidine extended yeast, fly, and worm lifespan by up to 30% via induction of autophagy; effects were abrogated by autophagy inhibition.

Resveratrol activates SIRT1, improving insulin sensitivity and extending lifespan in obese mice fed a high-fat diet.

Berberine reduced LDL cholesterol by 25% and triglycerides by 35% in patients with hyperlipidemia via upregulation of LDL receptor expression.

Creatine supplementation combined with resistance training increased bench press strength by 14% and squat strength by 8% compared to exercise alone.